INNV-25. ASSESSING SLEEP AND CIRCADIAN RHYTHMS IN PRIMARY BRAIN TUMORS PATIENTS: AN OBSERVATIONAL STUDY

Abstract Sleep-wake disturbances are among the most common and severe symptoms in primary brain tumor (PBT) patients. Currently, no studies have quantified their physiological sleep measurements or compared these assessments to established patient reported outcome measures (PROs). Smart wearable devices, such as Fitbits, continuously monitor behaviors at home provide detailed of sleep, activity, heart rate. We hypothesized that smart devices can accurately determine circadian disruptions will complement PROs a PBT population. This observational, cross-sectional trial monitors rhythm variables using Fitbit worn for 1 month. Additionally, participants answer questionnaires (PROMIS Sleep Disturbance Related Impairment-Short Forms, Hygiene Index, Morningness-Eveningness questionnaire, Consensus Diary) study entry during last week on-study. The present is planned interim analysis 54 patients assess feasibility, including evaluation enrollment, attrition, parameter completion data missingness. 73 were screened approached. Of patients, (74%) enrolled on 19 (26%) declined participation (8 lacked interest, 3 discomfort wearing watches, phone, 2 unable wear device work, attend consent calls, pregnancy cognitive complication). accrued 56% male, 56%³ 50 years age, 81% had KPS³ 90. Patients represented different stages treatment: 6% newly diagnosed, 24% active treatment (11% 1st recurrence, 13% 2nd recurrence), 70% imaging surveillance. Feasibility was confirmed there deviations 100% timepoints completed. Quantified percent time physiologic parameters be reported. Study enrollment efficacy continues.